AMT1 — Candida albicans

Summary

C3_02310W_A (AMT1, also known as MEP1) in Candida albicans encodes an ammonium transporter, belonging to the ammonium/urea transporter family with an AmtB-like domain, and functions as a methylammonium transmembrane transporter and ammonium channel. This gene is associated with ammonium import across the plasma membrane, nitrogen utilization, and cellular responses to nitrogen starvation. It is linked to the regulation of morphogenesis, biofilm formation, flocculation, cell-cell adhesion, TOR signaling, and responses to iron. Phenotypic associations include abnormal biofilm formation, absent flocculation, increased virulence, decreased nitrogen source utilization, and increased sporulation. The gene product localizes to the plasma membrane, fungal-type vacuole, and Golgi complex. Studies of related genes in other species link the family to protein and phosphate content.