SNF2 — Candida albicans

Summary

CaSNF2 (C3_02490C_A) on chromosome 3 of Candida albicans encodes an ATP-dependent chromatin remodeler with helicase activity, DNA translocase activity, and histone reader functions including H3K14ac and H4 recognition. The protein contains SNF2_N, helicase ATP-binding, bromodomain, and SnAC domains. CaSNF2 is associated with nucleosome organization, disassembly, and replication-dependent chromatin assembly, as well as heterochromatin boundary formation, transposable element silencing, and telomeric heterochromatin attachment to the nuclear envelope. It is linked to chlamydospore formation, cellular pheromone response, copper response, kinetochore assembly, and DNA double-strand break processing. Localization evidence links CaSNF2 to the SHREC complex, PBAF complex, CHRAC, heterochromatin islands, and CENP-A-containing chromatin. Phenotypic associations include increased thermotolerance, altered carbon source utilization, abnormal cell fusion, increased transposable element transposition, and premature cell cycle transitions through G1/S and G2/M phases.