MNT1 — Candida albicans

Summary

C3_01830C_A (MNT1, also known as MNT2) in Candida albicans chromosome 3 encodes a mannosylphosphate transferase with alpha-1,2-mannosyltransferase activity, belonging to the Glyco_trans_15 and nucleotide-diphossugar_trans families. The gene is associated with protein O-linked and N-linked glycosylation, mannan anabolism, cell wall biogenesis and organization, biofilm formation, cell-cell and cell-matrix adhesion, asexual sporulation, secretion, and immune response. It is linked to mitigation of host defenses, interaction with host, and candidiasis. The encoded protein localizes to the Golgi membrane, ER membrane, plasma membrane, cytoplasm, cytosol, and nucleus, and is also found extracellularly. Related genes in other species encode alpha-1,2-mannosyltransferases.