CAP1 — Candida albicans

Summary

CAP1 (C3_02220W_A) in Candida albicans encodes a bZIP transcription factor of the AP-1-like family, possessing DNA-binding transcription activator activity specific to RNA polymerase II, along with nucleosome and cis-regulatory region binding. It is associated with the regulation of metabolism, including heme and IMP biosynthesis, hexose catabolism, and responses to oxidative stress such as detoxification of hydrogen peroxide and singlet oxygen. CAP1 is linked to macrophage activation, cytokine production, peroxisome autophagy, and lipid oxidation. The gene product localizes to the nucleus, cytoplasm, and chromatin, and is part of transcription regulator complexes. CAP1 has been connected to disseminated candidiasis and to traits including increased acquired thermotolerance, altered cell cycle progression, and changes in endocytosis, sporulation, and nutrient uptake.