ERG6 — Candida albicans

Summary

C3_02150C_A (ERG6) on Candida albicans chromosome 3 encodes a sterol 24-C-methyltransferase (EC 2.1.1.41) of the SMT methyltransferase family, with sterol 24C methyltransferase activity. The gene is associated with ergosterol and zymosterol anabolism, sterol metabolism, plasma membrane polarization, response to basic pH, quorum sensing, biofilm formation, hyphal growth, cell adhesion, cell wall organization, aerobic respiration, fermentation, mitotic recombination, and protein folding. It localizes to the endoplasmic reticulum, plasma membrane, mitochondria, nucleus, and adiposome. Associations include increased adhesion, abnormal filamentous growth, absent anaerobic growth and hyperosmotic stress resistance, delayed shmoo formation and endocytosis, decreased cell death and cell fusion, increased polyploidy and aneuploidy, and altered cell cycle progression. Studies of related genes in other species link the family to reduced virulence.