TFP1 — Candida albicans

Summary

C3_01630W_A (TFP1, also known as VMA-1) on Candida albicans chromosome 3 encodes a protein with domains characteristic of the V-type ATPase catalytic subunit A and possesses proton-transporting ATP synthase activity, proton-transporting ATPase activity, endonuclease activity, and binds ATP, ADP, and DNA. TFP1 is associated with vacuolar acidification, proton transmembrane transport, ATP metabolism, mitochondrial ATP synthesis, cellular chemical homeostasis, endocytosis, filamentous growth, and responses to oxidative stress. It localizes to the vacuolar membrane, mitochondrial inner membrane, and cytosol. The gene is linked to traits including oxidative stress response, alkaline pH resistance, vacuolar morphology, filamentous growth, adhesion, endocytosis, sporulation efficiency, and hydrostatic pressure resistance. Related genes in other species are linked to zinc, calcium, and acid sensitivity.