PRP2 — Candida albicans

Summary

CaPRP2 (C3_01560W_A) encodes a DEAD/DEAH box helicase with 3'-5' RNA helicase activity, ATP binding, and hydrolase activity, and is associated with ribosomal small subunit binding and dsRNA binding. This gene is linked to spliceosome complex disassembly, formation of catalytic spliceosomes, and RNA-protein complex biogenesis. It is associated with abnormal cell cycle progression through the G2/M phase transition, delayed chromosome segregation, and altered recovery from pheromone-induced cell cycle arrest. CaPRP2 is also associated with absent respiratory metabolism, increased mating efficiency, absent nuclear fusion during mating, and abnormal carbon source utilization. Localization evidence places the product in the nucleolus, spliceosomal complexes, and the SSU processome. Studies of related genes in other species link the family to RNA helicase function and spliceosomal components.