PYRG — Candida albicans

Summary

C3_01350C_A (PYRG, also known as URA3) on Candida albicans chromosome 3 encodes a protein with orotidine-5'-phosphate decarboxylase and orotate phosphoribosyltransferase activities (EC 4.1.1.23), placing it in the OMPdecase family. The gene is associated with 'de novo' UMP and pyrimidine biosynthesis, as well as uridine and histidine anabolism. It has been linked to numerous phenotypes including decreased biofilm formation, reduced filamentous and invasive growth, altered adhesion, abnormal bud morphology, increased chronological lifespan, and altered stress resistance. The encoded product localises to the cytosol and the fungal biofilm matrix, and is associated with processes such as cell migration, phagocytosis, inflammatory and immune responses, adhesion of symbiont to host, and response to cyclophosphamide. Studies of related genes in other species link the family to oxidative stress response.