PMA1 — Candida albicans

Summary

C3_00720W_A (PMA1) in Candida albicans encodes a P-type ATPase family protein, specifically a proton-transporting ATPase (EC 7.1.2.1) with proton binding, ATP hydrolase, and metal binding activities, as well as annotated manganese and calcium transporter activities. The gene is associated with germ tube formation, cell pH regulation, cellular calcium and manganese ion homeostasis, glucose metabolism, cell polarization, and immune responses such as mucosal immune response and IL-17A production. PMA1 localizes to lipid rafts, Golgi membrane, ER, and extracellular vesicles. Phenotypic associations include abnormal spore germination, decreased cell death, altered hyperosmotic stress resistance, abnormal plasma membrane morphology, and increased nutrient uptake. Studies of related genes in other species link the family to potassium content and protein transport.