MP65 — Candida albicans

Summary

C2_10030C_A (MP65, also known as SCW10 or SCW4) on Candida albicans chromosome 2 encodes a glycoside hydrolase family 17 protein with glucan endo-1,3-beta-D-glucosidase activity, localizing to the yeast-form and hyphal cell walls, extracellular vesicles, and plasma membrane. The gene is associated with T cell activation, proliferation, polarization, cytokine production, and type IV hypersensitivity, as well as antigen processing and cell recognition. It is linked to biofilm formation, cell-substrate adhesion, germ tube formation, and response to host and cAMP. Phenotypic associations include altered filamentous and pseudohyphal growth, decreased invasive growth and adhesion, increased biofilm formation, abnormal cell wall morphology, decreased chitin deposition, increased alkaline pH resistance, and changes in mating efficiency, sporulation, and vegetative growth. Related genes in other species are associated with cell wall glucanase activity and acid sensitivity.