CIS3 — Candida albicans

Summary

C2_08870C_A (CIS3, also known as PIR1) in Candida albicans encodes a yeast cell-wall mannoprotein of the PIR family, with 1,3-beta-D-glucan binding and structural cell-wall constituent activity. The gene is associated with fungal-type cell wall biogenesis and organization, biofilm formation, hyphal and filamentous growth, chlamydospore formation, mating, immune evasion, and phagocytosis. It is linked to cell wall and biofilm matrix localisation, as well as extracellular presence. Associations include vitamin, glucan, and ergosterol anabolism, oxidative phosphorylation, demethylation, and cellular response to thermal stimulus. Phenotypic associations include increased thermotolerance, desiccation resistance, and altered cell cycle progression, along with decreased adhesion, chitin deposition, and invasive growth. Studies of related genes in other species link the family to acid sensitivity, oxidative stress response, and increased virulence.