BSC1 — Candida albicans

Summary

C2_09530W_A (BSC1, also known as EAP1) in Candida albicans encodes a flocculin family protein containing flocculin type-3 repeats and is annotated as a cell-cell adhesion molecule with CAM binding activity. The gene is associated with cell-cell recognition, adhesion of symbiont to host, biofilm formation, germ tube formation, flocculation, quorum sensing, and immune response processes. It localizes to the external side of the cell wall and plasma membrane, as well as the hyphal cell wall. Phenotypic associations include abnormal biofilm formation, increased adhesion, altered flocculation, increased mating efficiency, and absent resistance to osmotic and oxidative stress. The gene is also linked to candidiasis and disseminated candidiasis. Studies of related genes in other species connect the family to polysaccharide content and beta-glucan content traits.