KIS1 — Candida albicans

Summary

C2_09230C_A (KIS1, also known as CaGAL83, CaSIP2, GAL83, or SIP2) on chromosome 2 of Candida albicans encodes a protein containing ASC and AMPK1_CBM domains, with signaling receptor complex adaptor activity, enzyme-substrate adaptor activity, protein kinase regulator activity, and protein kinase binding. The gene is associated with the CAMKK-AMPK signaling cascade, regulation of response to stress, response to oxidative stress, invasive growth in response to glucose limitation, regulation of carbohydrate metabolism, cell aggregation, mating, detoxification, and cellular response to xenobiotic stimulus. It localizes to the nucleotide-activated protein kinase complex, plasmalemma, cytoplasm, cytosol, and nucleus. Phenotypic associations include decreased spore germination rate, absent fermentative growth, increased anaerobic growth, increased freeze-thaw resistance, and altered cell cycle progression. Studies of related genes in other species link the family to acid sensitivity.