ERG-3 — Candida albicans

Summary

C2_09400C_A (ERG-3, ERG24) on Candida albicans chromosome 2 encodes a protein with a sterol reductase domain and D14-sterol reductase activity (EC 1.3.1.70) and NADP binding, localised to the endoplasmic reticulum. The gene is associated with ergosterol anabolism, sterol metabolism and anabolism, biofilm formation, filamentous growth of a population of unicellular organisms in response to biotic stimulus, hyphal growth, morphogenesis, fermentation, vacuolar acidification, pH reduction, wound healing, demethylation, methylation, and cellular response to xenobiotic stimulus. Associations with numerous phenotypes include abnormal plasma membrane morphology, vacuolar transport defects, decreased invasive growth, increased cell death, and absent mating response. Studies of related genes in other species link the family to salt tolerance, phosphate content, acid sensitivity, and oxidative stress response.