CKI1 — Candida albicans

Summary

CKI1 (CaCKI1) on Candida albicans chromosome 2 encodes a Ser/Thr kinase with protein tyrosine kinase activity, ATP binding, and EC 2.7.11.1. It is associated with regulation of filamentous growth, biofilm formation, cell wall organization, endocytosis, cell polarity maintenance, and response to glucose and stress. The gene is linked to arginine breakdown, demethylation, the glyoxylate and TCA cycles, and heterotrophy. Localization evidence connects it to the vacuole, cell periphery, extracellular vesicles, cell tip, division site, plasma membrane, cytoplasm, and nucleus. Associations include oxidative stress response and numerous phenotypes: absent biofilm formation, osmotic stress resistance, and desiccation resistance; abnormal ER, Golgi, and vacuolar morphology; decreased intracellular transport; premature G2/M transition; increased anaerobic growth and freeze-thaw resistance; and cell cycle arrests in G2, telophase, and late anaphase.