GDH2 — Candida albicans

Summary

C2_07900W_A (GDH2, CaGDH-1) on Candida albicans chromosome 2 encodes a protein with NAD-GDH_euk, NAD-GDH_N, NAD-GDH_2nd, Glu/Leu/Phe/Val_DH_AS, Glu/Leu/Phe/Val/Trp_DH_C, Aminoacid_DH-like_N_sf, and NAD(P)-bd_dom_sf domains, and has L-glutamate dehydrogenase (NAD+) activity (EC 1.4.1.2). The protein localises to mitochondria and cytoplasm/cytosol. It is associated with ethanol anabolism, proline breakdown, glutamate breakdown, alcohol metabolism, methanol metabolism, amino acid breakdown, sphingolipid metabolism, the glucose effect, the TCA cycle, oxidative phosphorylation, mitochondrial translation, hyphal growth, and morphogenesis. Associations include biomass yield, absent fermentative growth, normal exponential growth rate, abnormal redox state, abnormal cytokinesis, abnormal budding, abnormal protein transport, arrested cell cycle progression, abnormal G1 phase progression, abnormal vegetative growth, abnormal colony appearance, abnormal cellular morphology, decreased and increased cell size, increased colony sectoring, increased stress resistance, increased metal resistance, increased RNA accumulation, increased chemical compound excretion, absent respiratory growth, decreased heat sensitivity, increased and decreased chronological lifespan, decreased stress resistance, haploproficient, decreased starvation resistance, increased protein/peptide accumulation, decreased nitrogen