PDT1 — Candida albicans

Summary

C2_07160W_A (PDT1, SMF12) in Candida albicans encodes a member of the NRAMP family of metal ion transporters, with molecular functions including metal ion and manganese ion transmembrane transporter activity and metal binding. The gene is associated with a wide range of biological processes, including manganese and iron ion transport and homeostasis, detection of symbiotic fungi, phagocytosis, host invasion, morphogenesis, cell wall biogenesis and organization, ergosterol and sterol metabolism, sulfur amino acid metabolism, and cellular response to xenobiotic stimulus. It is localized to the ER membrane and plasmalemma. Phenotypic associations include abnormal Golgi distribution, increased polyploidy rate, decreased spore germination, increased endocytosis, abnormal replicative lifespan, absent fermentative growth and budding, delayed cell cycle passage through START, altered pheromone sensitivity and production, decreased critical cell size at the G1 checkpoint, increased S phase duration, absent mitophagy, increased mating response, and decreased utilization of iron sources. Studies of related genes in other species link the family to manganese concentration and iron, copper, and calcium sensitivity.