TOR — Candida albicans

Summary

C2_07330W_A, also known as TOR1 or TOR, encodes a serine/threonine-protein kinase with protein kinase activity, histone H2A kinase activity, and pre-rRNA binding. It contains multiple domains including FRB, mTOR, TOR catalytic, and PI3/4-kinase domains. TOR1 is associated with the TOR complex, TORC1, and the ATR-ATRIP complex, and localizes to nucleolar chromatin and perinuclear cytoplasm. The gene is linked to regulation of cell growth, nitrogen catabolite repression, glycogenolysis, and glycan biosynthesis. Phenotypic associations include increased virulence, abnormal cell cycle progression, decreased polyploidy, absent sporulation efficiency, altered carbon and nitrogen source utilization, and increased protein transport. TOR1 is also associated with oxidative stress response and regulation of double-strand break repair.