OLE1 — Candida albicans

Summary

C2_07090C_A (OLE1, also known as OLE2) in Candida albicans encodes a stearoyl-CoA 9-desaturase, an enzyme with electron transfer activity that binds iron and heme, and belongs to the acyl-CoA desaturase family. This gene is associated with unsaturated fatty acid, lipid A, prostaglandin, and ergosterol biosynthesis, as well as fatty acid metabolism. It is linked to biofilm formation, chlamydospore formation, pseudohyphal and hyphal growth, morphogenesis, response to heat, secretion, and cell death. The encoded protein localizes to the endoplasmic reticulum membrane, including perinuclear and cortical ER. Phenotypic associations include abnormal filamentous growth, absent anaerobic growth and hyperosmotic stress resistance, increased alkaline pH resistance, decreased cell death, and altered endocytosis, vacuolar transport, and cell cycle progression. Studies of related genes in other species link the family to fatty acid regulation.