CTA4 — Candida albicans

Summary

CTA4 (SPF1) on Candida albicans chromosome 2 encodes a P5A-type ATPase, a member of the P-type ATPase family with E1-E2 ATPase and cation-transporting ATPase activity, and is annotated with membrane protein dislocase activity, phosphatidylinositol-4-phosphate binding, and calcium ion binding. The gene is associated with extraction of mislocalized protein from the ER membrane, release of sequestered calcium ion into cytosol by Golgi, manganese ion transport, sterol homeostasis, cell pH regulation, and regulation of fungal-type cell wall biogenesis. It localizes to the cis-Golgi network, Golgi membrane, ER membrane, nuclear envelope, and extracellular vesicles. CTA4 is linked to traits including oxidative stress response, and phenotypes such as increased alkaline pH resistance, abnormal chitin deposition, increased aneuploidy, altered colony shape, and increased hydrostatic pressure resistance. Studies of related genes in other species link the family to reduced virulence and loss of pathogenicity.