LSP1 — Candida albicans

Summary

C2_06730W_A (LSP1, also known as CaLSP1, PIL2, PIL1, CaPIL2, CaPIL1) in Candida albicans chromosome 2 encodes a protein belonging to the PIL1/LSP1 family and the AH/BAR domain superfamily, with lipid-binding molecular function. The gene is associated with eisosome assembly, plasma membrane and membrane organization, biofilm formation, hyphal growth, invasive growth, morphogenesis, secretion, response to stress, cell cycle control, phosphatidylserine anabolism, ATP anabolism, TCA cycle, sumoylation, nucleocytoplasmic transport, and adiposome localization to the forespore membrane leading edge. It localizes to the eisosome, plasma membrane, ascus membrane, prospore membrane leading edge, mitochondrial outer membrane, and nuclear membrane. Phenotypic associations include abnormal filamentous growth, decreased endocytosis, increased necrotic cell death, altered cell cycle progression, abnormal plasma membrane morphology, increased pheromone sensitivity, and absent meiosis and cell fusion. Related genes in other species link it to protein localization to the linear eisosome.