OGM4 — Candida albicans

Summary

C2_06100W_A (OGM4, also known as PMT4) in Candida albicans chromosome 2 encodes a protein with protein O-mannosyltransferase activity (EC 2.4.1.109). The gene is associated with protein O-linked glycosylation, fungal-type cell wall organization, filamentous growth, biofilm formation on inanimate substrates, cell-substrate adhesion, morphogenesis, the MAPK cascade, calcium signaling, interaction with host, immune response, and cellular responses to neutral pH, starvation, and xenobiotic stimuli. It is linked to regulation of the ER unfolded protein response and downregulation of proteolysis. The protein localizes to the ER membrane, nuclear membrane, endomembrane system, and plasma membrane. Associations with candidiasis and with mannose content have been noted. Phenotypic connections include abnormal budding, mating, shmoo formation, pheromone sensitivity, chitin deposition, cytokinesis, pexophagy, and filamentous growth, as well as increased cell death and sterile phenotypes.