IVN1 — Candida albicans

Summary

Candida albicans gene C2_05110W_A (IVN1, also known as LEM3, CDC50, or MUG89) on chromosome 2 encodes a member of the CDC50/LEM3 family, a protein with aminophospholipid flippase activity, phosphatidylcholine flippase activity, and ATP hydrolase activity. It is associated with phospholipid translocation, lipid transport and homeostasis, membrane biogenesis, endocytosis, phagocytosis, biofilm formation, hyphal and filamentous growth, regulation of vacuole organization, cell surface receptor signaling, homologous recombination, and the meiotic cell cycle. The protein localizes to the plasma membrane, endoplasmic reticulum, Golgi complex, late endosome, and the APLT complex. Phenotypic associations include decreased flocculation and adhesion, abnormal filamentous and pseudohyphal growth, altered endocytosis, delayed cell cycle progression, abnormal Golgi and plasma membrane morphology, and increased alkaline pH resistance. Related genes in other species link the CDC50/LEM3 family to zinc and acid sensitivity and oxidative stress response.