PYK1 — Candida albicans

Summary

C2_05460W_A (PYK1, also known as CDC19) in Candida albicans encodes a pyruvate kinase, an enzyme that exhibits pyruvate kinase activity, ATP binding, magnesium ion binding, potassium ion binding, and melatonin binding. The gene is associated with canonical glycolysis, the glycolytic process, fermentation, aerobic respiration, and the electron transport chain. It is linked to biofilm formation, filamentous growth in response to starvation and biotic stimulus, cell adhesion, morphogenesis, cell division, cytoskeleton organization, and the cellular response to stress and starvation. Associations with the perturbation of host immune response and angiogenesis have also been noted. The encoded protein localises to the cytoplasm, cytosol, mitochondria, plasma membrane, yeast-form and hyphal cell walls, and the fungal biofilm matrix. Phenotypic associations include increased adhesion, premature apoptosis, increased necrotic cell death, decreased cell death, delayed autophagy, absent spore germination, and decreased fermentative metabolism.