CDC7 — Candida albicans

Summary

C2_05140W_A (CDC7, also known as CDC15) in Candida albicans chromosome 2 encodes a protein with MEKK activity and protein serine/threonine kinase activity, belonging to the MAP kinase kinase kinase family. This gene is associated with multiple MAPK cascades, including the JNK cascade, p38 cascade, and pheromone response pathway, as well as RAM/MOR signaling and the septation initiation network (SIN). It is linked to mitotic cytokinesis, contractile ring assembly, regulation of microtubule dynamics, and activation of mitotic division septum assembly. The protein localizes to the mitotic spindle pole body, actomyosin contractile ring, division septum, cell tip, and cell division site. Studies of related genes in other species link the family to non-specific serine/threonine protein kinase activity (EC 2.7.11.1) and STE20/SPS1-PAK domain function.