NDH51 — Candida albicans

Summary

C2_04550C_A (NDH51, also known as NUO51 or CaNUO51) on Candida albicans chromosome 2 encodes a protein with NADH-UbQ_OxRdtase_suF, Nuo51_FMN-bd, SLBB_dom, NADH-UbQ_OxRdtase_51kDa_CS, ComplexI_51kDa_subunit, and Nuop51_4Fe4S-bd domains, and is associated with ubiquinone reductase activity, NAD binding, 4Fe-4S cluster binding, FMN binding, redox activity, and metal binding. The gene is associated with aerobic respiration, the electron transport chain, oxidative phosphorylation, and electron transfer, as well as the glyoxylate cycle and fermentation. It is linked to cytokine production, IL22 production, innate immunity, phagocytosis, mannan anabolism, and filamentous growth of a population of unicellular organisms in response to starvation. Additional associations include cell size control, the mitotic cell cycle, S phase, single-species biofilm formation on inanimate substrate, and cellular responses to glucose starvation and starvation. The product localizes to the mitochondrial inner membrane, mitochondria, and plasma membrane. Related genes in other species are linked to NADH dehydrogenase activity.