HIS3 — Candida albicans

Summary

C2_04810W_A (HIS3) on Candida albicans chromosome 2 encodes imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19), an enzyme with imidazoleglycerol-phosphate dehydratase activity. The gene is associated with histidine anabolism, immune response, phenotypic switching, biofilm formation, cell cycle, mitosis, nuclear division, spindle assembly, and homeostasis. Phenotypic associations include abnormal plasma membrane and nucleolar morphology, increased cell death and biofilm formation, decreased invasive growth, altered colony appearance, increased filamentous growth, decreased cell size, altered budding pattern, decreased resistance to ionic stress, acid pH, UV, and enzymatic treatment, increased thermotolerance and metal resistance, and abnormal vegetative growth. Related genes in other species link the family to abnormal liquid culture appearance.