SSN3 — Candida albicans

Summary

C2_04260W_A (SSN3, CaSSN3) on Candida albicans chromosome 2 encodes a cyclin-dependent kinase (CDK) with RNA polymerase II CTD heptapeptide repeat kinase activity (EC 2.7.11.23) and protein serine/threonine kinase activity. The gene is associated with the mediator complex and nucleus, and is linked to biofilm formation, hyphal growth, mating, negative regulation of filamentous growth, and cellular respiration. It is associated with response to host iron concentration and carbon dioxide, as well as positive and negative regulation of transcription by RNA polymerase II. Phenotypic associations include abnormal or absent flocculation, absent biofilm formation, increased adhesion, decreased budding rate, and changes in cell cycle progression, fermentative metabolism, and absent mating type switching. Studies of related genes in other species link SSN3 to potassium concentration and acid sensitivity traits.