PDR16 — Candida albicans

Summary

C2_02680W_A, also known as PDR16 or PDR17 in Candida albicans, encodes a CRAL-TRIO domain-containing protein with phosphatidylcholine intramembrane carrier activity, phosphatidylinositol carrier activity, and sterol binding. This gene is associated with phospholipid transport, intermembrane phospholipid transfer, Golgi vesicle budding, and the Kennedy pathway. It is linked to germ tube formation, quorum sensing, nitrogen utilization, and oxidative stress response. Localization evidence connects the protein to the Golgi membrane, endosome membrane, plasma membrane, cell tip, cell division site, and fungal biofilm matrix. Phenotypic associations include decreased endocytosis, abnormal Golgi morphology, arrested mitotic cell cycle, decreased meiosis, absent cytokinesis, increased exponential phase growth, absent autophagy, and abnormal endomembrane system morphology. Related genes in other species link the family to phosphatidylinositol transfer and phospholipid metabolism.