GPM1 — Candida albicans

Summary

C2_03270W_A (GPM1) on Candida albicans chromosome 2 encodes a phosphoglycerate mutase (EC 5.4.2.11) belonging to the His_PPase_superfam and PG/BPGM_mutase_AS families. The gene is associated with canonical glycolysis and gluconeogenesis, and is linked to host interaction processes including adhesion of symbiont to host, immune evasion, and innate immunity. It is also associated with morphogenesis, cell death, response to oxidative stress, secretion, and translation. The product localises to the hyphal cell wall, fungal-type cell wall, fungal biofilm matrix, cytosol, nucleus, and mitochondria. Phenotypic associations include decreased axial budding, abnormal septum formation, absent endocytosis and cytokinesis, increased vegetative growth rate, decreased spore germination, increased apoptosis, and decreased survival in stationary phase. Related genes in other species link the family to similar metabolic and stress-response functions.