HOG1 — Candida albicans

Summary

C2_03330C_A (HOG1) on Candida albicans chromosome 2 encodes a mitogen-activated protein (MAP) kinase with serine/threonine kinase activity, annotated as ERK1, and binds calmodulin, chromatin, and ATP. The gene is associated with the regulation of filamentous growth in response to biotic and heat stimuli, the glyoxylate cycle, PKC and protein kinase A activation, polyol anabolism, intracellular glycerol accumulation, nitrosative stress and salinity responses, energy homeostasis, lipid oxidation, cell-cell signaling, and short- and long-term memory. It is linked to systemic and disseminated candidiasis and infection. Phenotypic associations include absent osmotic stress resistance, decreased cell cycle progression rate, absent mating efficiency, increased acquired thermotolerance, and abnormal or absent flocculation. The protein localizes to the cytoplasm and nucleus.