ERG7 — Candida albicans

Summary

C2_02460W_A (ERG7) on Candida albicans chromosome 2 encodes a squalene cyclase (EC 5.4.99.7), a terpenoid cyclase. The gene is associated with ergosterol, sterol, triterpenoid, heme and helvolic acid anabolism, as well as secondary metabolism, fermentation, biofilm formation, wound healing, sterol import and demethylation. The product localises to the endoplasmic reticulum membrane, cytosol and adiposome. Phenotypic associations include absent anaerobic growth, abnormal plasma membrane morphology, increased cell death, decreased invasive growth, arrested vegetative and exponential-phase growth, abnormal cell size and budding patterns, premature cell cycle progression in metaphase and telophase, and decreased spore germination, nutrient uptake and vacuolar transport.