CREB — Candida albicans

Summary

C2_00970C_A (CREB/UBP13) on Candida albicans chromosome 2 encodes a thiol-dependent deubiquitinase (EC 3.4.19.12) with metal-dependent deubiquitinase activity, belonging to the peptidase C19 and ubiquitin-specific protease families. The gene is associated with carbon catabolite repression of transcription, regulation of protein stability, deubiquitination, ubiquitin-dependent proteolysis, endocytosis, autophagy, and cell cycle processes. It localizes to the cell tip, cell division site, cytosol, and nucleus. Phenotypic associations include increased G2/M phase transition, increased X-ray resistance, increased fermentative metabolism and carbon source utilization, decreased osmotic and ionic stress resistance, decreased cold sensitivity, abnormal meiosis and chromosome segregation, and arrested vegetative growth and exponential phase growth. Studies of related genes in other species link the family to oxidative stress response.