SNF2 — Candida albicans

Summary

Candida albicans SNF2 (C2_02100W_A) encodes a protein with ATP-dependent chromatin remodeler activity, helicase activity, histone binding, DNA translocase activity, and histone H4 reader activity, placing it in the SNF2 family of chromatin regulators. The gene is associated with nucleosome organization and disassembly, DNA double-strand break processing, transposable element silencing, heterochromatin boundary formation, and regulation of RNA polymerase II transcription preinitiation complex assembly. It is linked to filamentous growth regulation, chlamydospore formation, cellular pheromone response, and copper response. Phenotypic associations include increased thermotolerance, altered cell cycle progression through G1/S and G2/M transitions, abnormal cell fusion, increased transposable element transposition, and changes in carbon source utilization and fermentative growth. The protein localizes to multiple chromatin-associated complexes including SHREC, CHRAC, and PBAF, as well as heterochromatin islands and centromeric regions.