SOD5 — Candida albicans

Summary

C2_00680C_A (SOD5) on chromosome 2 of Candida albicans encodes a copper/zinc superoxide dismutase with superoxide dismutase activity, copper binding, and metal binding functions, belonging to the SOD_Cu/Zn/chaperone and filamin/ABP280 repeat-like families. The gene is associated with cellular response to superoxide, superoxide metabolism, removal of O2-, evasion or tolerance of host-produced reactive oxygen species, immune evasion, host invasion, opsonization, metabolic burst, response to host, and candidiasis and disseminated candidiasis. It is linked to processes including fatty acid oxidation, glyoxylate cycle, aerobic respiration, carnitine anabolism, sterol metabolism, sumoylation, electron transfer, glucose effect, and digestion. The product localizes to the yeast-form and hyphal cell walls, fungal-type cell wall, extracellular vesicles, side of membrane, and plasmalemma, and is also associated with the oxidative stress response. Related genes in other species link the superoxide dismutase family to cell surface functions.