NDT80 — Candida albicans

Summary

C2_00140W_A (NDT80, CaNDT80) on Candida albicans chromosome 2 encodes a fungal transcriptional regulator with an NDT80 DNA-binding domain, a p53-like transcription factor DNA-binding superfamily domain, and DNA-binding transcription activator activity. The gene is associated with nuclear and chromatin localization, and linked to cellular responses to N-acetyl-D-glucosamine, lithium ion, and copper, as well as filamentous growth, germ tube formation, biofilm regulation, phagocytosis, sexual reproduction, and sucrose metabolism. It has been connected to candidiasis and to traits including glucose content. Phenotypic associations include effects on meiosis, sporulation efficiency, spore germination, cell cycle progression, chromosome segregation, mating type switching, UV resistance, and radiation resistance. Related genes in other species link the NDT80 family to RNA accumulation.