ARO8 — Candida albicans

Summary

Candida albicans ARO8 (C2_00340C_A) encodes a class-I pyridoxal-phosphate-dependent aminotransferase with aromatic aminotransferase, tryptophan-phenylpyruvate transaminase, 2-aminoadipate transaminase, and L-tyrosine-2-oxoglutarate transaminase activities (EC 2.6.1.57). The gene is associated with aromatic amino acid and lysine biosynthesis, aromatic amino acid and tryptophan catabolism, nitrogen catabolite repression, quorum sensing, biofilm formation, mating, and morphogenesis. The protein localizes to the cytoplasm, cytosol, and nucleus. Phenotypic associations include abnormal nitrogen utilization, altered adhesion, increased biofilm formation, decreased acquired thermotolerance, increased mutation frequency, increased mitotic recombination, increased telomere length, decreased prion inheritance, increased autophagy, decreased sporulation efficiency, and abnormal colony shape, mitochondrial distribution, and lipid particle morphology. Studies of related genes in other species link the family to aromatic amino acid transamination.