FIP1 — Candida albicans

Summary

C1_14130W_A (FIP1, also known as FTR1) on Candida albicans chromosome 1 encodes a high-affinity ferrous iron transmembrane transporter belonging to the FTR1/Fip1/EfeU family. The gene product is associated with reductive iron assimilation, iron ion membrane transport, and cellular response to iron ion starvation. It is linked to diverse biological processes including biofilm formation, hyphal growth, quorum sensing, cell adhesion, immune evasion, interaction with host, phagocytosis, ER stress response, sphingolipid metabolism, lipid homeostasis, detoxification, secretion, and regulation of cell growth. Localisation evidence connects the protein to the high-affinity iron permease complex, plasmalemma, and Golgi complex. Phenotypic associations include increased stress resistance, increased metal resistance, increased innate thermotolerance, increased cold sensitivity, decreased acid and alkaline pH resistance, decreased anaerobic and fermentative growth, abnormal cell shape and budding, and altered sporulation efficiency. The gene is also linked to candidiasis.