ROB1 — Candida albicans

Summary

C1_13620W_A (ROB1) in Candida albicans chromosome 1 encodes a Zn2Cys6 DNA-binding transcription factor with sequence-specific DNA-binding and RNA polymerase II cis-regulatory region binding activity. The gene is associated with biofilm formation, filamentous growth, mating, morphogenesis, endocytosis, membrane depolarization, phagocytosis, pheromone response, and regulation of transcription by RNA polymerase II. It has been linked to disseminated candidiasis in a mouse model. The encoded protein localizes to the nucleus, cytosol, and chromatin. Studies of related genes in other species link the family to uncharacterized transcriptional regulatory functions.