MCS4 — Candida albicans

Summary

C1_13930W_A (MCS4/SSK1) in Candida albicans encodes a protein with a CheY-like superfamily domain and a signal transduction response regulator receiver domain, and is annotated with histidine kinase activity, phosphorelay sensor kinase activity, protein kinase activator activity, phosphorelay response regulator activity, and ATP binding. This gene is associated with regulation of cellular response to oxidative stress, regulation of filamentous growth of a population of unicellular organisms, inflammatory response, osmolarity sensing via two-component system, activation of p38 cascade, glutathione anabolism, upregulation of filamentous growth in response to neutral pH, histidyl-aspartyl phosphorelay, phagocytosis, localization, flocculation, cellular HOG response, immune evasion, negative regulation of mitotic entry, host invasion, ER stress response, cellular response to neutral pH, and filamentous growth in response to neutral pH. Phenotypic associations include abnormal filamentous growth, increased mating efficiency, increased anaerobic growth, abnormal bipolar budding pattern, delayed endocytosis, decreased cell cycle progression, increased cell cycle progression in M phase, increased cell cycle progression through the G2/M phase transition, delayed cell cycle passage through the metaphase-anaphase transition, decreased entry into G0, abnormal entry into G0, absence of osmotic stress resistance, absence of hyperosmotic stress resistance, absence of desiccation resistance, absence of pheromone sensitivity, sterile, decreased flocculation, delayed