CHS3 — Candida albicans

Summary

C1_13110C_A (CHS3) on Candida albicans chromosome 1 encodes a chitin synthase with chitin synthase activity (EC 2.4.1.16), containing a chitin synthase domain and a CHS4-like domain. The gene is associated with cell wall assembly, chlamydospore formation, germ tube formation, ascospore wall assembly, and asexual sporulation. It is linked to chitin breakdown and regulation of chitin anabolism, as well as glycerol anabolism, cholesterol anabolism, IL-1 production, and upregulation of DNA replication. Localization evidence connects the product to the chitosome, plasmalemma, incipient cellular bud site, cellular bud neck, cross wall, and extracellular vesicles. Phenotypic associations include decreased septum formation, abnormal chitin deposition, decreased adhesion, increased alkaline pH resistance, and various cell cycle alterations including delayed G2 progression and arrested anaphase. Related genes in other species link the family to chitin synthase function.