CHO1 — Candida albicans

Summary

C1_11240C_A (CHO1, also known as PPS1 or CaPPS1) in Candida albicans chromosome 1 encodes a CDP-diacylglycerol-serine O-phosphatidyltransferase (EC 2.7.8.8). This gene is associated with phosphatidylserine metabolism, phosphatidylethanolamine anabolism, ATP anabolism, the Kennedy pathway, phospholipid metabolism, cell wall organization or biogenesis, plasma membrane organization, quorum sensing, filamentous growth of a population of unicellular organisms in response to chemical stimulus and starvation, and cellular responses to K+ ion and Ca2+ ion. The encoded protein localises to the ER membrane, plasmalemma, mitochondrial outer membrane, cytoplasmic vesicle membrane and cytosol. CHO1 is associated with copper sensitivity, and with phenotypes including abnormal pseudohyphal growth, decreased colony size, increased rate of apoptosis, abnormal chitin deposition, abnormal septum formation, decreased lifespan, and abnormal or delayed endocytosis, vacuolar transport, protein secretion and nutrient uptake.