PMT3 — Candida albicans

Summary

Candida albicans PMT3 (also known as SMT3, CaSUMO, or CaPMT3) on chromosome 1 encodes a protein with a Rad60/SUMO-like domain and a ubiquitin-like domain. The gene is associated with E3 protein ligase binding, protein tag, and identical protein binding. PMT3 is associated with sumoylation, protein modification, cellular responses to stress and heat, hyphal growth, morphogenesis, cytokinesis, fermentation, secretion, and signal transduction. It localizes to the nucleus, mitotic spindle pole body, septin ring, and cellular bud neck. Phenotypic associations include delayed cell cycle progression through G1/S and anaphase, abnormal chromosome segregation, absent meiosis and anaerobic growth, increased fermentative growth, and decreased micronucleophagy and nucleophagy. Studies of related genes in other species link the family to telomere maintenance and cell cycle control.