PAC2 — Candida albicans

Summary

C1_10150W_A (PAC2, also known as WOR1) in Candida albicans encodes a Gti1/Pac2 family protein with sequence-specific DNA binding and transcription factor activity. This gene is associated with regulation of cell fate determination, phenotypic switching, mating behavior, and parasexual conjugation with cellular fusion. It is also linked to memory, epigenetic regulation of gene expression, nucleosome assembly, the glyoxylate cycle, and biofilm formation on inanimate substrates. The encoded protein localizes to the nucleus, chromatin, cytosol, and mitotic spindle pole body. Studies of related genes in other species link the family to reduced virulence, and changes in stress resistance, though these associations are not established for C. albicans.