TPK1 — Candida albicans

Summary

C1_10220C_A (TPK1) on Candida albicans chromosome 1 encodes a protein with AGC-kinase and protein kinase domains, exhibiting cAMP-dependent protein kinase, ribosomal protein S6 kinase, and protein serine/threonine kinase activities, along with lipid binding and signaling adaptor functions. This gene is associated with regulation of cAMP anabolism, glycogen metabolism, and sphingolipid biosynthetic processes, as well as positive regulation of transcription by RNA polymerase III and cytoplasmic translation. It is linked to downregulation of filamentous growth, cell adhesion in biofilm formation, and TORC2 signaling, and to negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling. The encoded protein localizes to the cAMP-dependent protein kinase complex, cytoskeleton, P bodies, stress granules, and sites of polarized growth. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence.