SRE — Candida albicans

Summary

C1_10020W_A (SRE, also known as SFU1 or CaFEP1) on chromosome 1 of Candida albicans encodes a GATA-family transcription factor with iron sensor activity, capable of binding DNA, 2Fe-2S clusters, and zinc. This gene is associated with cellular responses to iron and copper, iron-sulfur cluster assembly, iron ion homeostasis and transport, downregulation of ferrichrome anabolism and iron transport, riboflavin anabolism, nitric oxide storage, biofilm formation, mitochondrial biogenesis, and morphogenesis. It is linked to both negative and positive regulation of transcription by RNA polymerase II, and localises to chromatin, the cytoplasm, and the nucleus. Associations with polysaccharide content and iron concentration have been recorded. Studies of related genes in other species link the family to oxidative stress response and southern corn leaf blight.