SHO1 — Candida albicans

Summary

C1_09140C_A (SHO1, also known as SSU81) on chromosome 1 of Candida albicans encodes a protein containing an SH3 domain and is annotated with F-actin binding activity. The gene is associated with the cortical actin cytoskeleton, the site of polarized growth, and the plasma membrane. It is linked to numerous biological processes including protein kinase A activation, regulation of actin polymerization, mannan anabolism, positive regulation of filamentous growth, cell-substrate adhesion, quorum sensing, immune response, flocculation, cell wall assembly, host invasion, the MAPK cascade, and cell morphogenesis. Phenotypic associations include absent toxin resistance, absent osmotic and oxidative stress resistance, absent biofilm formation, absent alkaline pH resistance, increased adhesion, increased mating efficiency, abnormal filamentous growth, and decreased cell cycle progression. Studies of related genes in other species link the family to salt tolerance and oxidative stress response.