ACUE — Candida albicans

Summary

C1_09690W_A (ACUE, also known as MLS1) in Candida albicans encodes a malate synthase (EC 2.3.3.9), a key enzyme of the glyoxylate cycle. The gene is associated with multiple biological processes including the glyoxylate cycle, gluconeogenesis, fatty acid beta-oxidation, and the breakdown of glucose, acetate, and fatty acids, as well as ATP anabolism and the TCA cycle. The encoded protein localises to the glyoxysome, peroxisome, and cytoplasm. ACUE is associated with abnormal vegetative growth, decreased cell size, altered biofilm formation, increased mutation frequency, and absence of sporulation and innate thermotolerance. It is also linked to decreased respiratory metabolism, abnormal mitochondrial and peroxisomal morphology, impaired peroxisomal transport, and altered survival rates in stationary phase. Related genes in other species link the family to filamentous growth and oxidative stress response.