ADB — Candida albicans

Summary

C1_09640W_A (symbol ADB, also known as ADE12) in Candida albicans encodes an adenylosuccinate synthetase, an enzyme with adenylosuccinate synthase activity (EC 6.3.4.4) that also binds GTP and magnesium and is associated with de novo AMP biosynthesis, IMP metabolism, and adenine biosynthesis. The gene is associated with cell pH elevation, carotene anabolism, germ tube formation, hyphal growth, biofilm formation, fermentation, glucose metabolism, DNA replication origin binding, homologous recombination, non-homologous end joining, mitotic recombination, gene conversion, G2 phase cell cycle progression, and tRNA processing. Phenotypic associations link ADB to increased nutrient and carbon source uptake, increased flocculation and filamentous growth, decreased alkaline pH resistance, decreased acquired thermotolerance, increased telomere length, abnormal budding and cellular morphology, and altered prion inheritance and sporulation efficiency. The encoded protein localizes to the cytoplasm.