ERG1 — Candida albicans

Summary

C1_08590C_A (ERG1) on Candida albicans chromosome 1 encodes a squalene monooxygenase (EC 1.14.14.17) with squalene epoxidase and FAD/NAD-binding domains. ERG1 is associated with ergosterol metabolism, sterol import, and sterol, sphingolipid, fatty acid, heme, riboflavin, and glucan anabolism. It is linked to PKC signal transduction, quorum sensing, filamentous growth in response to chemical stimuli, germ tube formation, cell growth mode switching from budding to filamentous, and regulation of gene expression. The gene product localizes to the endoplasmic reticulum, ER membrane, plasma membrane, vacuolar membrane, adiposome, and cytoplasm. Phenotypic associations include absent anaerobic growth and endocytosis, decreased invasive growth, autophagy, ribophagy, shmoo formation, and nutrient uptake, increased vegetative growth rate and mating response, and abnormal septum formation, cytokinesis, cell cycle progression, and redox state.